Study of the binding mechanism between aptamer GO18-T-d and gonyautoxin 1/4 by molecular simulation.
نویسندگان
چکیده
GTX1/4 can induce the formation of an antiparallel G-quadruplex structure in aptamer GO18-T-d and combine steadily in the groove at the top of the G-quadruplex structure. The complex structures and special induced fit mechanism between aptamer and small molecules provide a reference for aptamer development in molecular diagnostics and therapeutic application.
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ورودعنوان ژورنال:
- Physical chemistry chemical physics : PCCP
دوره 18 34 شماره
صفحات -
تاریخ انتشار 2016